Preparation of Nucleoside-Carbohydrate Phosphodiester Prodrug Analogues by Chemoenzymatic Procedure

Chemoenzymatic preparation of germacrene analogues.

A small library of novel germacrenes was generated using a combination of two plant enzymes, germacrene A synthase, and D synthase and modified farnesyl diphosphate (FDP) analogues. This chemoenzymatic approach allows the preparation of potentially valuable volatiles for biological studies.

An efficient solid phase synthesis of 5'-phosphodiester and phosphoramidate monoester nucleoside analogues.

An easy and efficient strategy to obtain libraries of 5'-phosphodiester and 5'-phosphoramidate monoester nucleoside analogues in a highly pure form has been developed, starting from a new nucleoside based solid support. The nucleoside scaffold has been anchored through a 5'-phosphodiester linkage to Tentagel HL resin, functionalized with a 3-chloro-4-hydroxyphenylacetic linker. The solid phase ...

Chemical Synthesis of Nucleoside Analogues Chemical Synthesis of Nucleoside Analogues

Chemoenzymatic preparation of germacrene analoguesw

Terpenoids represent a valuable class of bioactive fine chemicals and are therefore attractive targets for synthetic modification; modulation of their natural properties may lead to new medicinal and agrochemical compounds with improved properties. However, the complexity of the hydrocarbon skeletons and the often significant chemical instability of many terpenoids can present a formidable chal...

Invited Review Chemoenzymatic Transformations in Nucleoside Chemistry

During the last quarter of the century almost no other aspect of organic synthesis has received as much attention as the preparation of enantiomerically pure compounds. The synthesis of optically active materials is an important task and represents a challenge to synthetic organic chemists. Increasing interest in the understanding of biological processes and the general recognition that chirali...